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CYCLIN DEPENDENT KINASE INHIBITOR P27
Descriptors Found:
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DeCS
Descriptor
English
:
Cyclin-Dependent Kinase Inhibitor p27
Descriptor
Spanish
:
Inhibidor p27 de las Quinasas Dependientes de la Ciclina
Descriptor
Portuguese
:
Inibidor de Quinase Dependente de Ciclina p27
Synonyms
English
:
CDK Inhibitor p27
CDKN1B Protein
CDKN4 Protein
Cyclin-Dependent Kinase Inhibitor 1B
p27 CDK Inhibitor
p27 Kip1 Protein
p27Kip1 Protein
CDK Inhibitor, p27
Cyclin Dependent Kinase Inhibitor 1B
Cyclin Dependent Kinase Inhibitor p27
Kip1 Protein, p27
p27, CDK Inhibitor
Tree Number:
D12.644.360.225.600
D12.776.167.187.600
D12.776.476.225.600
D12.776.624.776.355.600
Definition
English
:
A cyclin-dependent kinase inhibitor that coordinates the activation of
CYCLIN
and
CYCLIN-DEPENDENT KINASES
during the
CELL CYCLE
. It interacts with active
CYCLIN D
complexed to
CYCLIN-DEPENDENT KINASE 4
in proliferating cells, while in arrested cells it binds and inhibits
CYCLIN E
complexed to
CYCLIN-DEPENDENT KINASE 2.
Pharmacological Action:
Protein Kinase Inhibitors
History Note
English
:
2006(1992)
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AG
agonists
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
CT
contraindications
DF
deficiency
DE
drug effects
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
SE
secretion
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UL
ultrastructure
UR
urine
Record Number:
50932
Unique Identifier:
D050760
Occurrence in VHL
:
Similar:
DeCS
CID-10
SciELO
LILACS
LIS